EDP Sciences portal
   15 Jul 04 Mirror sites: France | Japan | USA      
    First visit | Contacts | EDPS' sites | Useful links | Suggestion box | FAQ
find an article DOI resolver
Advanced search      
  The European Physical Journal B 
All issues     Special issues     Online first     Forthcoming papers
Vol.   1st page
EDPS Link Manager Help

Table of contents  |  < -   Abstract   - >

Recommend this article  |  PDF  |  References
Eur. Phys. J. B 37, 109-115 (2004)
DOI: 10.1140/epjb/e2004-00035-y

Characterizing neuromorphologic alterations with additive shape functionals

M.S. Barbosa1, L. da F. Costa1, E.S. Bernardes2, G. Ramakers3 and J. van Pelt3

1  Cybernetic Vision Research Group, GII-IFSC, Universidade de São Paulo, São Carlos, SP, Caixa Postal 369, 13560-970, Brasil
2  DFCM-IFSC, Universidade de São Paulo, São Carlos, SP, Caixa Postal 369, 13560-970, Brasil
3  Neurons and Network, Netherlands Institute of Brain Research, Meibergdreef 33, 1105 AZ Amsterdam, The Netherlands


(Received 31 July 2003 / Received in final form 10 November 2003 / Published online 19 February 2004)

The complexity of a neuronal cell shape is known to be related to its function. Specifically, among other indicators, a decreased complexity in the dendritic trees of cortical pyramidal neurons has been associated with mental retardation. In this paper we develop a procedure to address the characterization of morphological changes induced in cultured neurons by over-expressing a gene involved in mental retardation. Measures associated with the multiscale connectivity, an additive image functional, are found to give a reasonable separation criterion between two categories of cells. One category consists of a control group and two transfected groups of neurons, and the other, a class of cat ganglionary cells. The reported framework also identified a trend towards lower complexity in one of the transfected groups. Such results establish the suggested measures as an effective descriptors of cell shape.

87.80.Pa - Morphometry and stereology.
87.19.La - Neuroscience.

© EDP Sciences, Società Italiana di Fisica, Springer-Verlag 2004
EDP Sciences
17, avenue du Hoggar - Parc d'Activités de Courtaboeuf - BP 112 - F-91944 Les Ulis Cedex A - France